Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Arrangement and localization of the human GM-CSF receptor alpha chain gene CSF2RA within the X-Y pseudoautosomal region.

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.

A proteome-scale map of the human interactome network.

Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.

Phosphorylated SHC1 recruits GRB2:GAB2

Phosphorylated SHC recruits GRB2:SOS1

Gab2 binds the p85 subunit of Class 1A PI3 kinases

RAS GEFs promote RAS nucleotide exchange

CSF2RA:CSF2RB binds SFTPs

SFTPs translocate from extracellular region to clathrin-coated vesicle

Defective CSF2RB does not bind SFTPs

Defective CSF2RA does not bind SFTPs

Tyrosine kinases phosphorylate the receptor

Activation of STAT5a/b by JAK2

JAK2 is phosphorylated, activated

SHC1 bound to the common beta chain becomes tyrosine phosphorylated

STAT5 is recruited by JAK2

Recruitment of SHC1 is mediated by Y593 of the common beta chain

The receptor is activated

SHP1 and SHP2 bind the common beta chain

SHC1 mediates cytokine-induced phosphorylation of GAB2

p-S585-IL3RB binds 14-3-3 proteins

GM-CSF receptor alpha subunit binds GM-CSF

GM-CSF receptor alpha:GM-CSF binds Bc

Phosphorylated SHC1 recruits SHIP

The SHC1:SHIP1 complex is stabilized by GRB2

IL3RB is phosphorylated on Ser-585

SHP1 and SHP2 dephosphorylate Y628 of IL3RB

14-3-3 zeta binding allows recruitment of PI3K

p-STAT5 dissociates from the receptor complex

A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain.

Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor.

Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor.

Discovery and characterization of a novel splice variant of the GM-CSF receptor alpha subunit.

Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1.

Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.

Growth hormone acts on the synthesis and secretion of alpha-casein in bovine mammary epithelial cells.