Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling.

Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.

A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells.

Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses.

Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA.

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling.

ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.

Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.

DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells.

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

TRIM56 is an essential component of the TLR3 antiviral signaling pathway.

TRAM is required for TLR2 endosomal signaling to type I IFN induction.

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.

WDFY1 mediates TLR3/4 signaling by recruiting TRIF.

FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Supramolecular organizing centers at the interface of inflammation and neurodegeneration.

PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-κB Signaling Pathway.

Regulation of innate immune signaling by IRAK proteins.

TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)

Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex

IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4

K63-linked ubiquitination of RIP1 bound to the activated TLR complex

TRIF:activated TLR3/TLR4 complex recruits RIP1

Viral dsRNA:TLR3 recruits TRIF (TICAM1)

Viral dsRNA:TLR3:TRIF complex recruits RIP1

Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex

Activation of recruited TAK1 within the activated TLR3 complex

Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6

TRAF3 binds TICAM1:activated TLR4 complex

Auto-ubiquitination of TRAF3

SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14

TLR4-induced ripoptosome assembly

Caspase-8 processing within TLR4 complex

RIP3 binds TRIF to mediate necroptosis

Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex

Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation

TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4

TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4

Defective TRAF3 does not transmit the signal

TICAM1 deficiency blocks TLR3 pathway

Phosphorylated TAK1 dissociates from the TLR3 receptor complex

TLR3-induced ripoptosome assembly

Caspase-8 processing within TLR3 complex

RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis

Auto-ubiquitination of TRAF3 within activated TLR3 complex

Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex

IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3

TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3

TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA

TRAF3 binds to TRIF:activated TLR3 complex

SARM binds viral dsRNA:TLR3:TICAM1

K63-linked ubiquitination of RIP1 bound to the activated TLR complex

IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex

Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex

Activation of TAK1 complex bound to activated TLR4 complex

Auto ubiquitination of TRAF6 bound to the activated TLR4 complex

Activated TLR4:TICAM1 recruits TRAF6

IKBKG subunit of IKK complex binds polyubiquinated RIP1

Phosphorylated TAK1 leaves activated TLR receptor complex

Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation

TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4

TBK1 is phosphorylated within the activated TLR4 complex

Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4

Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4

OPTN binds TBK1 within the activated TLR4 complex

IKKε (IKBKE) is ubiquitinated within the activated TLR4

IKKε (IKBKE) is phosphorylated within the activated TLR4 complex

TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3

TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3

IKKε (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3

TBK1 is phosphorylated within the activated TLR3 complex

OPTN binds TBK1 within the activated TLR3 complex

IKKε (IKBKE) is phosphorylated within the activated TLR3 complex

IKKε (IKBKE) is ubiquitinated within the activated TLR3 complex

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.

Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.

Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.

TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells.

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

UniProt entry Q8IUC6 (TICAM1_HUMAN)

Falcon deep research report on TICAM1