Falcon deep research report for PFDN2
UniProt record for human PFDN2
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UniProt curates PFDN2 as a component of both the canonical prefoldin complex and the PAQosome/R2TP prefoldin-like complex, with nucleus, cytoplasm, and mitochondrion localization from PMID:17936702.
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II.
Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization.
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PFDN2 interacts with HCV F protein via yeast two-hybrid and co-IP
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HCV F protein impedes PFDN1-PFDN2 interaction
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Disruption leads to aberrant tubulin cytoskeleton organization
Large-scale mapping of human protein-protein interactions by mass spectrometry.
S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling.
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PFDN2 interacts with URI1 in phosphorylation-dependent manner
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PFDN2 localizes to nucleus, cytoplasm, and mitochondria
Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Architecture of the human interactome defines protein communities and disease networks.
RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.
The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.
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Cryo-EM structure of prefoldin-TRiC complex
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Conserved electrostatic interface between PFD and TRiC
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PFD enhances folding rate and yield
Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome.
A reference map of the human binary protein interactome.
The functions and mechanisms of prefoldin complex and prefoldin-subunits.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A comprehensive analysis of prefoldins and their implication in cancer.
Multimodal cell maps as a foundation for structural and functional genomics.
Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.
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Discovery of prefoldin as heterohexameric chaperone
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Prefoldin captures unfolded actin and delivers to cytosolic chaperonin
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Promotes folding in competitive environment