Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Combined Automated Annotation using Multiple IEA Methods.
Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes.
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Stomatin is an integral membrane protein strongly associated with the phospholipid bilayer
"Human red blood cells (RBCs) that are deficient in an integral membrane-associated protein ("stomatin") of apparent molecular mass 31 Kd show a catastrophic increase in passive membrane permeability to the univalent cations Na+ and K+ and are stomatocytic in shape."
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Stomatin also binds to the cytoskeleton
"Selective solubilization studies using detergents show that while the protein is strongly associated with the phospholipid bilayer, it also binds to the cytoskeleton."
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Stomatin deficiency causes increased passive membrane permeability to Na+ and K+
"Human red blood cells (RBCs) that are deficient in an integral membrane-associated protein ("stomatin") of apparent molecular mass 31 Kd show a catastrophic increase in passive membrane permeability to the univalent cations Na+ and K+ and are stomatocytic in shape."
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Stomatin is inferred to function by closing a latent ion channel
"By inference, the protein has the function of closing a latent ion channel."
Oligomeric nature of the integral membrane protein stomatin.
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Stomatin fundamental structure is oligomeric
"In this study, we demonstrate that the fundamental structure of stomatin is oligomeric."
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Stomatin forms homo-oligomeric complexes of 9-12 monomers
"The data indicate that these complexes comprise between 9 and 12 monomers of stomatin."
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C-terminus is required for homo-oligomeric interaction
"Two C-terminally truncated forms of stomatin do not incorporate into these oligomers, suggesting an involvement of the C terminus in the homo-oligomeric interaction."
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Stomatin is linked to cortical actin cytoskeleton
"There is also evidence that stomatin is linked to the cortical actin cytoskeleton, suggesting a role in cortical morphogenesis of the cell."
Stomatin is a major lipid-raft component of platelet alpha granules.
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Stomatin is a major lipid raft component
"Stomatin, a major lipid-raft component of erythrocytes and epithelial cells, is also an abundant platelet protein."
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Stomatin associates with alpha-granular lipid rafts in platelets
"Microscopical methods and subcellular fractionation showed that stomatin is located mainly at the alpha-granular membrane."
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Stomatin translocates to plasma membrane and is released in microvesicles upon activation
"Activation of platelets by calcium ionophore A23187 or thrombin led to translocation of stomatin to the plasma membrane, cleavage by calpain, and specific sorting into released microvesicles."
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Stomatin is cleaved by calpain upon activation
"Activation of platelets by calcium ionophore A23187 or thrombin led to translocation of stomatin to the plasma membrane, cleavage by calpain, and specific sorting into released microvesicles."
Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains.
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Stomatin interacts with GLUT1, AE1, and AQP1 in erythrocyte membranes
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Stomatin is part of large membrane protein complexes
Interaction of stomatin with hepatitis C virus RNA polymerase stabilizes the viral RNA replicase complexes on detergent-resistant membranes.
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Stomatin interacts with HCV NS5B RNA polymerase
"In this study, we took a proteomic approach to identify stomatin, a member of the integral proteins of lipid rafts, as a cellular protein interacting with HCV NS5B."
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Stomatin helps form enzymatically active HCV replication complexes on lipid rafts
"Our results identify stomatin as a cellular protein that plays a role in the formation of an enzymatically active HCV RC on a detergent-resistant membrane structure."
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Stomatin silencing inhibits HCV replication
"Stomatin silencing by RNA interference led to the release of NS5B from the detergent-resistant membrane, thereby inhibiting HCV replication in both HCV subgenomic replicon-harboring cells and HCVinfected cells."
Stomatin modulates the activity of the Anion Exchanger 1 (AE1, SLC4A1).
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Stomatin positively regulates AE1 Cl-/HCO3- exchange activity
"Here we show that stomatin modulates the transport activity of AE1 through a direct protein-protein interaction."
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Stomatin-deficient RBCs show 47% decreased permeability to HCO3- and 42% decreased Cl- efflux
"A significant decrease of 47% could be thus calculated from the means of these constants"
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Stomatin overexpression increases AE1 activity by 30%
"a significant increase of the AE1 activity (30.3%) was revealed in cells overexpressing stomatin"
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Stomatin interacts with AE1 through direct protein-protein interaction
"In situ Proximity Ligation Assays confirmed an interaction of AE1 with stomatin, in both HEK recombinant cells and RBCs."
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Stomatin likely interacts with dimeric forms of AE1 in the junctional complex
"the stomatin-actin association is consistent with the binding of stomatin to the dimeric forms of AE1 within the junctional complex and not to the tetrameric form in the ankyrin complex."
Stomatin-like protein-1 interacts with stomatin and is targeted to late endosomes.
A proteome-scale map of the human interactome network.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
Defining the membrane proteome of NK cells.
Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Protein profile of exosomes from trabecular meshwork cells.
Exocytosis of azurophil granule membrane proteins
Exocytosis of tertiary granule membrane proteins
Exocytosis of specific granule membrane proteins
Deep research report on STOM gene function
Cyberian deep research on STOM function