Falcon deep research report for SNORD116-1
-
Falcon supports copy-level SNORD116-1 annotation to structural, biogenesis, and localization concepts typical of box C/D snoRNAs, while treating Prader-Willi and neurodevelopmental phenotypes as cluster/locus evidence rather than direct SNORD116-1 functions.
"SNORD116-1 is best annotated with structural/biogenesis/localization GO concepts typical of box C/D snoRNAs, while not being annotated yet with specific RNA modification targets or disease-process terms."
Automatic Gene Ontology annotation of non-coding RNA sequences through association of Rfam records with GO terms
Roles of SNORD115 and SNORD116 ncRNA clusters during neuronal differentiation
Cognitive deficits in the Snord116 deletion mouse model for Prader-Willi syndrome
-
Snord116 deletion causes cognitive deficits in mice: deficits in novel object recognition, location memory, and tone cue fear conditioning
"We discovered deficits in Snord116+/- mutant mice in the novel object recognition, location memory and tone cue fear conditioning assays"
-
The Snord116 cluster deletion model shows learning and memory impairments relevant to PWS
"These results show that the Snord116+/- deletion murine model is a valuable preclinical model for investigating learning and memory impairments in individuals with PWS"
SNORD116 and growth hormone therapy impact IGFBP7 in Prader-Willi syndrome
Snord116 Post-transcriptionally Increases Nhlh2 mRNA Stability: Implications for Human Prader-Willi Syndrome
-
SNORD116 cluster deletion is the smallest genomic region causing Prader-Willi Syndrome
"The smallest genomic region causing Prader-Willi Syndrome (PWS) deletes the non-coding RNA SNORD116 cluster"
-
SNORD116 increases stability of Nhlh2 mRNA through direct interaction: upregulation occurs through increased mRNA stability in the 45 minutes immediately following transcription
"use of actinomycin D to stop new transcription in N29/2 cells demonstrated that the upregulation occurred through increased stability of the Nhlh2 mRNA in the 45 minutes immediately following transcription"
-
In silico modeling identified conserved interaction domains between SNORD116 and NHLH2 mRNA 3'-UTR
"In silico RNA: RNA modeling identified several potential interaction domains between SNORD116 and NHLH2 mRNA"
-
Mechanism: SNORD116-mediated regulation clarifies how deletion of SNORD116 cluster leads to PWS phenotypes
"For the first time, these data identify a motif and mechanism for SNORD116-mediated regulation of NHLH2, clarifying the mechanism by which deletion of the SNORD116 snoRNAs locus leads to PWS phenotypes"