Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus.
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The review places roughly 20 genes in the A. fumigatus ergosterol biosynthesis pathway, providing species-level pathway context for AFUA_5G10680.
"About 20 genes are involved in the A. fumigatus ergosterol biosynthesis pathway. There are several duplicated genes in this pathway."
Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus.
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Mevalonate supply links ergosterol and triacetylfusarinine C siderophore biosynthesis in A. fumigatus.
"Consistent with mevalonate being a limiting prerequisite for TAFC biosynthesis, we observed increased expression of 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase (Hmg1) under iron starvation"
UniProt entry Q4WV38 (ERG8_ASPFU)
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Swiss-Prot curates Q4WV38/AFUA_5G10680 as the A. fumigatus Erg8 phosphomevalonate kinase that converts 5-phosphomevalonate to 5-diphosphomevalonate.
"5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase erg8 (AFUA_5G10680)."
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Q4WV38 is classified in PANTHER subfamily PTHR31814:SF2, the fungal phosphomevalonate kinase subfamily.
"DR PANTHER; PTHR31814:SF2; PHOSPHOMEVALONATE KINASE; 1."
PAINT IBD nodes for PTHR31814
PTHR31814 fungal phosphomevalonate kinase family review