"requires NPHP-2 (known as inversin in mammals) to anchor a cGMP-gated ion channel within the proximal ciliary region"

"One compartment, a bona fide cilium, is delineated by proteins associated with Bardet-Biedl syndrome (BBS), Meckel syndrome and nephronophthisis at its base"

"the C. elegans inversin ortholog, NPHP-2, localizes to the middle segment of sensory cilia"

"nphp-2 is partially redundant with nphp-1 and nphp-4"

"nphp-2 also genetically interacts with MKS ciliopathy gene orthologs, including mks-1, mks-3, mks-6, mksr-1 and mksr-2, in a sensilla-dependent manner to control cilia formation and placement"

"nphp-2 is not required for correct localization of the NPHP- and MKS-encoded ciliary transition zone proteins or for intraflagellar transport (IFT)"

"nphp-2 plays an important role in C. elegans cilia by acting as a modifier of the NPHP and MKS pathways to control cilia formation and development"

"We show that the InvC is conserved and distinct from the doublet region."

"nphp-2 (the C. elegans Inversin homolog) and the doublet region genes arl-13, klp-11, and unc-119 are redundantly required for ciliogenesis."

"InvC and doublet region genes can be sorted into two modules-nphp-2+klp-11 and arl-13+unc-119-which are both antagonized by the hdac-6 deacetylase."

"These defects indicate that nphp-2 is required both for microtubule patterning and for cilia anchoring."

"NPHP-2 does require its calcium binding EF hand domain for targeting to the InvC."

"We conclude that NPHP-2 marks a region of the cilium distinct from the doublet region, and propose that this region is analogous to the InvC of mammalian cilia."

"the C. elegans homologues colocalize, albeit at epithelial junctions rather than cilia"

"we lack fundamental knowledge about how the components might assemble into a functionally active state"