Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas.
Structural basis of caspase-7 inhibition by XIAP.
Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain.
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease.
Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway.
Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex.
Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis.
Engineered hybrid dimers: tracking the activation pathway of caspase-7.
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.
Identification of novel regulators of apoptosis using a high-throughput cell-based screen.
Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.
Executioner caspase-3 and caspase-7 are functionally distinct proteases.
Dissecting an allosteric switch in caspase-7 using chemical and mutational probes.
Calpain-1 cleaves and activates caspase-7.
A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function.
Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells.
Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes.
Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines.
Phosphorylation of the transcription factor YY1 by CK2α prevents cleavage by caspase 7 during apoptosis.
Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease.
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis.
Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes.
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.
Structural asymmetry of procaspase-7 bound to a specific inhibitor.
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.
A proteome-scale map of the human interactome network.
Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.
Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms.
Characterization of Hsp90 Co-Chaperone p23 Cleavage by Caspase-7 Uncovers a Peptidase-Substrate Interaction Involving Intrinsically Disordered Regions.
Maximizing binary interactome mapping with a minimal number of assays.
Cellular substrates and pro-apoptotic function of the human HtrA4 protease.
Caspase-7 uses RNA to enhance proteolysis of poly(ADP-ribose) polymerase 1 and other RNA-binding proteins.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine.
Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32.
ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.
Cleavage of Procaspase-7 by the apoptosome
SMAC binds XIAP:Caspase-7
Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7
Caspase-mediated cleavage of vimentin at DSVD (85)
Caspase-mediated cleavage of FADK 1
Caspase-mediated cleavage of GAS2
Caspase-mediated cleavage of MST3
Caspase-mediated cleavage of claspin
Caspase-7 translocates to the nucleus
Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice.
Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice.
Caspase-7 activates ASM to repair gasdermin and perforin pores.