FTSH12: ProtNLM function review

Exact emitted record, retrieved 2026-09-10T14:34:40.348123+00:00.

Original prediction and assessment

Probable ATP-dependent zinc metallopeptidase

UNC (CS 1). The word “probable” is appropriate to the current protease uncertainty. FTSH12 retains the zinc-binding motif, but H769Y complementation preserves essential function and import, and N-terminomics does not identify an endogenous FTSH12 cleavage substrate. Neither a robust physiological metallopeptidase assignment nor an absolute absence of proteolysis is established. PMID:30309901(https://pubmed.ncbi.nlm.nih.gov/30309901/); PMID:33216923(https://pubmed.ncbi.nlm.nih.gov/33216923/).

The assessment concerns the selected accession A0A1P8ARD2. Other emitted outputs and evidence context.