Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Identification of sequence determinants for the ABHD14 enzymes.
-
ABHD14A lacks any functional annotation, in contrast to ABHD14B which was shown to be a lysine deacetylase.
"While ABHD14A still lacks any functional annotation to date, we"
-
High sequence similarity causes automated databases to wrongly assign ABHD14A and ABHD14B as the same enzyme, which has made functional annotation of both problematic.
"Given
their high sequence similarity, automated databases often wrongly assign ABHD14A
and ABHD14B as the same enzyme, and therefore, annotating functions to them in
various organisms has been problematic."
Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse.
Affinage mechanistic annotation for ABHD14A (human)