Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.
Mammalian Apg12p, but not the Apg12p.Apg5p conjugate, facilitates LC3 processing.
The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification.
Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes.
Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16.
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.
Network organization of the human autophagy system.
Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy.
Binding to E1 and E3 is mutually exclusive for the human autophagy E2 Atg3.
Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12.
Identification and characterization of the linear region of ATG3 that interacts with ATG7 in higher eukaryotes.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Semisynthetic LC3 Probes for Autophagy Pathways Reveal a Noncanonical LC3 Interacting Region Motif Crucial for the Enzymatic Activity of Human ATG3.
ATG16L1 complex transfers LC3 from ATG3 to PE
ATG3 transfers LC3 from ATG7 to ATG3
LC3:ATG7 dimer binds ATG3
ATG7:ATG3:LC3 dissociates
ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death.
Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge.
UniProtKB entry Q9NT62 (ATG3_HUMAN), Ubiquitin-like-conjugating enzyme ATG3