PA1810 (OppB) review notes

Identity

UniProt unreviewed entry, 615 aa, SBP_bac_5 (PF00496), Peptide/Ni-binding (IPR030678), PANTHER PTHR30290:SF64. SignalP signal peptide.
The opp-fabI operon paper calls the gene oppB but gives no PA numbers. The protein lengths fix the mapping
PMID:23979749:
Q9I2T3/PA1811 is 609 aa (OppA), Q9I2T4/PA1810 is 615 aa (OppB). PseudoCAP assigned the same IMP row to both loci.

Literature

Opp of P. aeruginosa is a binding protein-dependent ABC importer, oppA oppB oppC oppD oppE then fabI
PMID:23979749.
Both binding proteins are needed and neither substitutes for the other
PMID:23979749.
Here, the pacidamycin-resistant transposon mutant PAM1194 maps to oppB, and the unmarked oppB deletion PAO1284 is highly resistant while still expressing OppA.
Opp transports a dipeptide
PMID:23979749.
The authors suggest a heteromeric binding protein
PMID:23979749.

Literature search (2026-11-05): the PubMed MCP and NCBI E-utilities returned server errors all session, and
Europe PMC search was intermittently unavailable (HTTP 503), so the searches for "PA1811", "PA1810" and
"Pseudomonas aeruginosa Opp oligopeptide" returned nothing usable. The review rests on PMID:23979749 (full text
cached, PMC3811240, read in full), the UniProt record and QuickGO queries of the other seeds.

PseudoCAP IBA-seed assessment

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN008624512	GO:0015833 peptide transport	7	228 (38 taxa)	GO:0006857 oligopeptide transport, IMP, PMID:23979749	SOUND	Full text read: defined oppB mutant loses uptake of the peptide antibiotic pacidamycin; Opp transports PAbetaN. A periplasmic binding protein takes part in transport directly.	E. coli OppA P23843 (IDA GO:0006857), DppA P23847 (IMP/EXP dipeptide transport), YejA P33913 (IDA GO:0006857), GsiB P75797 (EXP glutathione transport), MppA P77348 (EXP murein tripeptide transport); PA1811 (same PseudoCAP row)	Yes; five E. coli seeds with experimental annotations (QuickGO, 2026-11-05)

No source_defects were recorded: the PseudoCAP row is sound, and the IBD is sound and suits a clade of
SBP family 5 peptide-binding proteins. The node is shared with PA1811; the assessment is the same on both
genes and is recorded in full here and in genes/PSEAE/PA1811/PA1811-notes.md.

Other IBA rows on this gene (not PseudoCAP-seeded):

GO:1904680 peptide transmembrane transporter activity (PTN008624512, seeded by M. tuberculosis OppA P9WGU5, MTBBASE IDA): accepted.
GO:0030288 outer membrane-bounded periplasmic space (PTN008624519, seed E. coli YejA): accepted.
GO:0042884 microcin transport (PTN008624519, seeded only by E. coli YejA): marked as over-annotated. Microcin C uptake is
a YejA substrate specificity; nothing links P. aeruginosa Opp to microcins. Not a PseudoCAP issue, so no defect is filed
here; the node term is a candidate for PAINT review at that subnode.

Action summary

ACCEPT 4 (GO:0006857 IMP, GO:0030288 IBA, GO:0043190 IEA, GO:1904680 IBA); TOO_GENERAL 2 (GO:0015833 IBA,
GO:0042597 IEA); MODIFY 1 (GO:0055085 to GO:0035672); MARK_AS_OVER_ANNOTATED 1 (GO:0042884 IBA).