file:ARATH/CERK1/CERK1-deep-research-falcon.md

Falcon (Edison Scientific) deep research report for CERK1

GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000003

Gene Ontology annotation based on Enzyme Commission mapping

GO_REF:0000116

Automatic Gene Ontology annotation based on Rhea mapping

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

GO_REF:0000122

AtSubP analysis

PMID:18042724

CERK1, a LysM receptor kinase, is essential for chitin elicitor signaling in Arabidopsis.

"CERK1 is a plasma membrane protein containing three LysM motifs in the extracellular domain and an intracellular Ser/Thr kinase domain with autophosphorylation/myelin basic protein kinase activity, suggesting that CERK1 plays a critical role in fungal MAMP perception in plants."

PMID:18263776

A LysM receptor-like kinase plays a critical role in chitin signaling and fungal resistance in Arabidopsis.

"LysM RLK1 is essential for chitin signaling in plants (likely as part of the receptor complex) and is involved in chitin-mediated plant innate immunity."

PMID:19249211

AvrPtoB targets the LysM receptor kinase CERK1 to promote bacterial virulence on plants.

"AvrPtoB ubiquitinates the CERK1 kinase domain in vitro and targets CERK1 for degradation in vivo."

PMID:19816132

The LysM receptor kinase CERK1 mediates bacterial perception in Arabidopsis.

"the Arabidopsis LysM receptor kinase CERK1 is required not only for chitin signalling and fungal resistance, but plays an essential role in restricting bacterial growth on plants"

PMID:19951949

Direct binding of a plant LysM receptor-like kinase, LysM RLK1/CERK1, to chitin in vitro.

"we present the first evidence for direct binding of LysM RLK1 to chitin"

PMID:20610395

The lysin motif receptor-like kinase (LysM-RLK) CERK1 is a major chitin-binding protein in Arabidopsis thaliana and subject to chitin-induced phosphorylation.

"the CERK1 ectodomain binds chitin and partially deacetylated chitosan directly without any requirement for interacting proteins and that all three LysM domains are necessary for chitin binding"

PMID:22106285

Arabidopsis lysin-motif proteins LYM1 LYM3 CERK1 mediate bacterial peptidoglycan sensing and immunity to bacterial infection.

"PGN sensing and immunity to bacterial infection in Arabidopsis thaliana requires three lysin-motif (LysM) domain proteins"

PMID:22461667

The LysM receptor-like kinase LysM RLK1 is required to activate defense and abiotic-stress responses induced by overexpression of fungal chitinases in Arabidopsis plants.

"chitin-induced signaling mediated by LysM RLK1 receptor is not limited to biotic stress response but also encompasses abiotic-stress signaling"

PMID:22654057

Chitin-induced dimerization activates a plant immune receptor.

"a chitin octamer induces AtCERK1-ECD dimerization that is inhibited by shorter chitin oligomers"

PMID:22740685

How plant lysin motif receptors get activated: lessons learned from structural biology.

"CERK1 binds NAG oligomers derived from chitin-the major constituent of fungal cell walls-and mediates immunity to fungal infection"

PMID:22744984

LYK4, a lysin motif receptor-like kinase, is important for chitin signaling and plant innate immunity in Arabidopsis.

"LYK1/CERK1 (for LysM-containing receptor-like kinase1/chitin elicitor receptor kinase1) was shown to be essential for chitin recognition"

PMID:24750441

Selective regulation of the chitin-induced defense response by the Arabidopsis receptor-like cytoplasmic kinase PBL27.

"PBL27, an Arabidopsis ortholog of OsRLCK185, is an immediate downstream component of the chitin receptor CERK1"

PMID:25036661

LIK1, a CERK1-interacting kinase, regulates plant immune responses in Arabidopsis.

"In vitro experiments showed that LIK1 was directly phosphorylated by CERK1"

PMID:25340959

The kinase LYK5 is a major chitin receptor in Arabidopsis and forms a chitin-induced complex with related kinase CERK1.

"AtLYK5 interacts with AtCERK1 in a chitin-dependent manner. Chitin binding to AtLYK5 is indispensable for chitin-induced AtCERK1 phosphorylation."

PMID:27317676

The Arabidopsis Malectin-Like/LRR-RLK IOS1 Is Critical for BAK1-Dependent and BAK1-Independent Pattern-Triggered Immunity.

"CHITIN ELICITOR RECEPTOR KINASE1 (CERK1) recognize microbe-associated molecular patterns (MAMPs) to activate pattern-triggered immunity (PTI)"

PMID:27679653

The Arabidopsis CERK1-associated kinase PBL27 connects chitin perception to MAPK activation.

"The Arabidopsis CERK1-associated kinase PBL27 connects chitin perception to MAPK activation"

PMID:29182677

Arabidopsis ubiquitin ligase PUB12 interacts with and negatively regulates Chitin Elicitor Receptor Kinase 1 (CERK1).

"the ARM domains of PUB12 and its paralog PUB13 interacted with the intracellular domain of CERK1 in a manner that was dependent on its autophosphorylation"