Gene Ontology annotation through association of InterPro records with GO terms
Use of the ND evidence code for Gene Ontology (GO) terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
SNO2-SNZ1 pyridoxal 5'-phosphate synthase complex
Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6.
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In media lacking vitamin B6, SNZ1 and SNO1 were required for growth in certain conditions, but SNZ2, SNZ3, SNO2 and SNO3 were not required; copies 2 and 3 are instead activated by lack of thiamine and appear more related to vitamin B1 biosynthesis during exponential phase.
"In media lacking vitamin B(6), SNZ1 and SNO1 were both required for growth in certain conditions, but neither SNZ2, SNZ3, SNO2 nor SNO3 were required."
The extremely conserved pyroA gene of Aspergillus nidulans is required for pyridoxine synthesis and is required indirectly for resistance to photosensitizers.
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The SNZ family (the PLP-synthase synthase subunit; pyroA in Aspergillus) is an enzyme specifically required for pyridoxine biosynthesis, defining the eukaryotic/archaeal PLP biosynthetic pathway that the SNO glutaminase subunit feeds.
"define this gene family as encoding an enzyme specifically required for pyridoxine biosynthesis"
Analysis of the pdx-1 (snz-1/sno-1) region of the Neurospora crassa genome: correlation of pyridoxine-requiring phenotypes with mutations in two structural genes.
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In Neurospora crassa, pyridoxine-requiring mutants carry mutations disrupting either the SNZ or the SNO homolog, and the SNO homolog corresponds to pdx-2; this establishes that a fungal SNO/glutaminase subunit is required for pyridoxine (PLP) biosynthesis.
"pyridoxine-requiring mutants of N. crassa were found to possess mutations that disrupt conserved regions in either the SNZ or SNO homolog"