Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Combined Automated Annotation using Multiple IEA Methods
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
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DAF-2 is an insulin receptor family member
"daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans."
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Regulates dauer diapause and longevity
"daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans."
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Induces metabolic changes analogous to mammalian insulin signaling
"daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans."
Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span.
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daf-2 mutants live more than twice as long as wild-type
"Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span."
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daf-2 functions cell-nonautonomously
"Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span."
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Regulates both dauer formation and adult lifespan
"Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span."
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling.
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DAF-2 signals through PI3K/AKT pathway
"Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling."
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DAF-2 prevents DAF-16 nuclear accumulation
"Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling."
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Lifespan extension requires DAF-16
"Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling."
Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity.
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HSF-1 required for DAF-2 effects on immunity
"Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity."
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daf-2 mutants have enhanced pathogen resistance
"Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity."
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.
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DAF-2/IIS directly inhibits SKN-1 in parallel to DAF-16
"Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans."
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SKN-1 contributes to longevity in daf-2 mutants
"Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans."
SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.
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SHC-1 directly interacts with DAF-2
"SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans."
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SHC-1 opposes IIS through DAF-2 interaction
"SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans."
Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16.
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PRMT-1 regulates DAF-16 in the daf-2 pathway
"Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16."
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daf-2 mutants show stress tolerance and fat storage
"Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16."
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
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DAF-2 negatively regulates autophagy
"TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO."
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daf-2 RNAi increases autophagic vesicles
"TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO."
Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development.
DAF-2 and ERK couple nutrient availability to meiotic progression during Caenorhabditis elegans oogenesis.
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DAF-2 signals through RAS-ERK in oogenesis
"DAF-2 and ERK couple nutrient availability to meiotic progression during Caenorhabditis elegans oogenesis."
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DAF-2 localizes to plasma membrane and cytoplasmic vesicles
"DAF-2 and ERK couple nutrient availability to meiotic progression during Caenorhabditis elegans oogenesis."
Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans.
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DAF-2c isoform translocates from cell body to synaptic region
"Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans."
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Required for taste avoidance learning
"Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans."
IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation in Caenorhabditis elegans.
Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans.
Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4.
Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells.
Specificity and complexity of the Caenorhabditis elegans innate immune response.
Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans.
A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication.
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans.
Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.
Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans.
Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety.
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DAF-2 signaling regulates feeding behavior and satiety responses
"Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety."
Functional interaction between beta-catenin and FOXO in oxidative stress signaling.
Modulation of Caenorhabditis elegans infection sensitivity by the LIN-7 cell junction protein.
Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans.
Timing requirements for insulin/IGF-1 signaling in C. elegans.
Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1.
The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.
Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation.
Deep research report on daf-2