daf-18 (G5EE01) review notes

Deep research: falcon run failed (timeout/connection reset; perplexity fallback unavailable). Review based on cached publications, UniProt and PubMed.

Key findings

• PTEN homolog acting as PIP3 phosphatase in vivo PMID:10377431
• daf-18 suppresses Daf-c of daf-2/age-1 PMID:10377431
• Protein phosphatase vs VAB-1 PMID:19853560
• Localisation: cytoplasm/nucleus then plasma membrane in VPCs PMID:22916028
• Blocks AKT membrane recruitment PMID:25383666

Curation decisions

• NAS "positive regulation of insulin receptor signaling pathway" (PMID:20207731) has an inverted sign: the abstract states DAF-18 "normally serves as a suppressor of DAF-2 signaling". MODIFY -> GO:0046627 negative regulation.
• IBA regulation of PI3K/PKB signalling -> negative regulation (GO:0051898).
• "protein phosphatase inhibitor complex" NAS marked over-annotated (co-complex with ARR-1/MPZ-1, no inhibitor activity shown; DAF-18 would be the target).
• Protein binding (VAB-1) -> ephrin receptor binding.
• Neuronal localisations from PMID:16950159 (abstract-only) deferred to curator.