TSC10 (YBR265W, P38342) notes

Identity and activity

• SDR-family 3-ketosphinganine reductase, NADPH-dependent, EC 1.1.1.102 PMID:9804843.
• Essential without exogenous LCB PMID:9804843.
• Used as positive control for bacterial 3-KDSR discovery PMID:35667415.

Location / topology

• Integral ER membrane protein with cytoplasmic catalytic domain PMID:19141869.
• Also found on lipid droplets PMID:24868093.
• Mitochondrial outer membrane only from HTP proteomics (PMID:16407407) - kept non-core.

Curation decisions

• RCA cytosol -> MODIFY to ER membrane. Human ortholog KDSR/FVT1 complements tsc10.