ASCC1 PN Consistency Notes
- Generated: 2026-06-18
- Project: PROTEOSTASIS
- Scope: PN consistency rereview against local AIGR review and available deep-research artifacts
- UniProt: Q8N9N2
- AIGR review status: COMPLETE
- Review batch: proteostasis-batch-2026-06-03 (PR 1370)
- Batch change status: added
Source Files Checked
Deep Research Files
AIGR Review Snapshot
- Description: ASCC1 encodes the p50 subunit of the nuclear activating signal cointegrator 1 complex. The protein acts with TRIP4/ASC-1, ASCC2, and ASCC3 in a transcription coactivator complex that supports AP-1, SRF, NF-kappaB, and context-specific gene-expression responses. ASCC1 also functions as an accessory/regulatory subunit of the ASCC alkylation-damage response, where it interacts with ASCC3 and helps coordinate recruitment and assembly of the ALKBH3-ASCC repair complex at nuclear alkylation-damage foci. ASCC1 localizes mainly to the nucleus and nuclear speckles; loss-of-function variants disrupt neuromuscular development and cause spinal muscular atrophy with congenital bone fractures.
- Existing/core annotation action counts: ACCEPT: 18; MARK_AS_OVER_ANNOTATED: 5; NEW: 2; REMOVE: 1
PN Consistency Summary
- Consistency: Internally consistent but PN placement is contradicted by the gene's own evidence. Deep research, notes, and review YAML all frame ASCC1 as a nuclear ASC-1/ASCC subunit (transcription coactivation + ALKBH3-linked alkylation-damage repair); none place ASCC1 in cytosolic ribosome rescue. The notes explicitly flag the RQC projection as a workbook propagation artifact and cite PMID:38366554 that ASCC1 is dispensable for the cytoplasmic ribosome-splitting step. GOA confirms no RQC term on ASCC1.
- PN story / NEW pressure: The PN asserts a ribosomal-rescue/RQC role not in GO and not supported by ASCC1-specific data. GO:0072344 and GO:0006515 are real terms, but projecting them to ASCC1 over-reaches: the RQC role belongs to the ASCC complex via ASCC3/ASCC2/TRIP4, with ASCC1 dispensable. Conclude: over-reaches (do not project to ASCC1). No defensible NEW GO term for ASCC1 from the PN node; the review already proposes the correct NEWs (GO:0060090 molecular adaptor; GO:0003713 transcription coactivator, contributes_to).
- Evidence alignment: PN row carries no reference titles; the review's RQC-adjacent papers (PMID:37092320 translation initiation; PMID:38366554 disassembly) are complex/ASCC3-centric and were deliberately not used to add RQC terms to ASCC1. No PMID conflict — divergence is conceptual (node-level vs gene-level).
- Verdict: Consistent review; PN RQC projection over-reaches for ASCC1 and is correctly rejected in-review. No edits needed beyond exempting ASCC1 from RQC propagation at the mapping layer.
Full Consistency Review
- UniProt: Q8N9N2 · batch: proteostasis-batch-2026-06-03 · review status: COMPLETE (rich; Falcon DR present)
- PN placement:
Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue ; PN-node mapping: type=mapped/ok GO:0072344 (rescue of stalled cytosolic ribosome); group=mapped/ok GO:0006515; class/branch context_only. Both projected terms new_to_goa.
- Consistency: Internally consistent but PN placement is contradicted by the gene's own evidence. Deep research, notes, and review YAML all frame ASCC1 as a nuclear ASC-1/ASCC subunit (transcription coactivation + ALKBH3-linked alkylation-damage repair); none place ASCC1 in cytosolic ribosome rescue. The notes explicitly flag the RQC projection as a workbook propagation artifact and cite PMID:38366554 that ASCC1 is dispensable for the cytoplasmic ribosome-splitting step. GOA confirms no RQC term on ASCC1.
- PN story / NEW pressure: The PN asserts a ribosomal-rescue/RQC role not in GO and not supported by ASCC1-specific data. GO:0072344 and GO:0006515 are real terms, but projecting them to ASCC1 over-reaches: the RQC role belongs to the ASCC complex via ASCC3/ASCC2/TRIP4, with ASCC1 dispensable. Conclude: over-reaches (do not project to ASCC1). No defensible NEW GO term for ASCC1 from the PN node; the review already proposes the correct NEWs (GO:0060090 molecular adaptor; GO:0003713 transcription coactivator, contributes_to).
- Mapping strategy: This gene is a counter-example for the RQC node, not a driver. The type/group mappings (GO:0072344/GO:0006515) are biologically sound for the node but must not be auto-projected to ASCC1. Status/scope of the node need not change for other members; ASCC1 should be exempted from propagation.
- Evidence alignment: PN row carries no reference titles; the review's RQC-adjacent papers (PMID:37092320 translation initiation; PMID:38366554 disassembly) are complex/ASCC3-centric and were deliberately not used to add RQC terms to ASCC1. No PMID conflict — divergence is conceptual (node-level vs gene-level).
- Verdict: Consistent review; PN RQC projection over-reaches for ASCC1 and is correctly rejected in-review. No edits needed beyond exempting ASCC1 from RQC propagation at the mapping layer.
PN Dossier Context
- review_batch: proteostasis-batch-2026-06-03
- review_yaml: genes/human/ASCC1/ASCC1-ai-review.yaml
- PN workbook rows: 1
PN row 1: Translation | Cytosolic translation | Ribosome-associated QC | Ribosomal rescue
- UniProt: Q8N9N2
- In branches: TR
- PN-node mapping records (path + ancestors):
- [type] Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue
status=mapped scope=ok_for_propagation_to_go GO=[GO:0072344 rescue of stalled cytosolic ribosome]
rationale: This PN RQC type denotes rescue of stalled cytosolic ribosomes. The matching GO process term is the direct target.
- [group] Translation|Cytosolic translation|Ribosome-associated QC
status=mapped scope=ok_for_propagation_to_go GO=[GO:0006515 protein quality control for misfolded or incompletely synthesized proteins]
rationale: The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.
- [class] Translation|Cytosolic translation
status=context_only scope=too_broad_to_propagate GO=[GO:0002181 cytoplasmic translation]
rationale: The PN class Cytosolic translation is centered on the cytoplasmic translation apparatus and process, but it also houses supporting machinery such as ribosome biogenesis factors. The GO process term is a useful high-level label for the class, but propagating it to all members would over-annotate genes whose PN placement is through assembly or maturation context rather than core cytoplasmic translation.
- [branch] Translation
status=context_only scope=too_broad_to_propagate GO=[GO:0006412 translation]
rationale: The PN Translation branch is organized around the translation apparatus and immediately associated cotranslational quality-control systems. GO translation is the closest high-level process label, but the PN branch also contains adjacent machinery such as ribosome biogenesis and nascent-chain handling. Keeping this relationship is useful for interpretation, but it is too broad to project safely onto every member.
Projected GO annotations (2)
- GO:0006515 protein quality control for misfolded or incompletely synthesized proteins | scope=ok_for_propagation_to_go | goa_status=new_to_goa | from=Translation|Cytosolic translation|Ribosome-associated QC
- GO:0072344 rescue of stalled cytosolic ribosome | scope=ok_for_propagation_to_go | goa_status=new_to_goa | from=Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue
Note
This file is generated from the current PROTEOSTASIS phase-1 dossier and local gene-review artifacts. Edit the source review, PN mapping, or dossier rather than this generated note when correcting the underlying curation.