GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms.

GO_REF:0000118

TreeGrafter-generated GO annotations

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods.

PMID:10198000

Transcriptional organization of the czc heavy-metal homeostasis determinant from Alcaligenes eutrophus.

Demonstrates that CzcR and CzcS form a two-component regulatory system involved in Zn2+, Co2+, and Cd2+-inducible regulation of the czc heavy-metal resistance determinant, and that purified CzcR binds DNA in the 5' region of the czc locus.

"The CzcR putative response regulator was purified and shown to bind in the 5' region of czcN."
Shows using czcR and czcS deletion mutants, reporter assays, and cDNA analysis that the CzcRS two-component system regulates czcCBA mRNA synthesis in response to zinc, cobalt, and cadmium.

"Experiments on (i) growth of these strains in liquid culture containing 5 mM Zn2+, (ii) induction of the beta-galactosidase in the reporter strains by zinc, cobalt, and cadmium, and (iii) cDNA analysis of czcCBA mRNA synthesis under inducing and noninducing conditions showed that the CzcRS two-component regulatory system is involved in Czc regulation."

file:VARPD/czcR/czcR-notes.md

Curation Notes for czcR (VPARA_44930, A0A0H2LVW5) in Variovorax paradoxus TBEA6

file:VARPD/czcR/czcR-uniprot.txt

UniProtKB record for Variovorax paradoxus TBEA6 czcR (A0A0H2LVW5)

VPARA_44930 is a 225-amino-acid heavy-metal response regulator classified in NCBIfam:TIGR01387 (cztR_silR_copR) and PANTHER:PTHR48111:SF76.

"DR NCBIfam; TIGR01387; cztR_silR_copR; 1."
Contains an N-terminal response regulatory receiver domain (residues 2-115; PROSITE:PS50110) with phosphoacceptor Asp-51, and a C-terminal OmpR/PhoB-type winged-helix DNA-binding domain (residues 123-221; PROSITE:PS51755).

"FT DOMAIN 2..115 FT /note="Response regulatory" FT /evidence="ECO:0000259|PROSITE:PS50110" FT DOMAIN 123..221 FT /note="OmpR/PhoB-type" FT /evidence="ECO:0000259|PROSITE:PS51755" FT DNA_BIND 123..221 FT /note="OmpR/PhoB-type" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091" FT MOD_RES 51 FT /note="4-aspartylphosphate" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169" "