Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Fertile hypomorphic ARGONAUTE (ago1) mutants impaired in post-transcriptional gene silencing and virus resistance.
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Hypomorphic ago1 mutations impair post-transcriptional gene silencing.
"We show that these hypomorphic ago1 mutants are defective for PTGS, like null sgs2, sgs3, and ago1 mutants"
The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development.
Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs.
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AGO1 participates in the biogenesis of endogenous trans-acting siRNAs.
"they require components of the cosuppression pathway (RDR6 and SGS3) and also components of the microRNA (miRNA) pathway (AGO1, DCL1, HEN1, and HYL1)"
Auxin and light control of adventitious rooting in Arabidopsis require ARGONAUTE1.
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AGO1-dependent root development is linked to auxin homeostasis and light responses.
"The defect in adventitious rooting observed in ago1 correlated with light hypersensitivity and the deregulation of auxin homeostasis specifically in the apical part of the seedlings."
Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAs.
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AGO1 directly associates with miRNAs and several siRNA classes.
"AGO1 is physically associated with miRNAs, transacting siRNAs, and transgene-derived siRNAs"
Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation.
Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense.
Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants.
The Polerovirus F box protein P0 targets ARGONAUTE1 to suppress RNA silencing.
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The viral suppressor P0 associates with AGO1 and promotes its destabilization.
"Finally, we provide evidence that P0 physically interacts with AGO1."
Vascular signalling mediated by ZWILLE potentiates WUSCHEL function during shoot meristem stem cell development in the Arabidopsis embryo.
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AGO1 contributes to embryonic stem-cell signaling in a sequence distinct from ZLL/AGO10.
"WUS-dependent OC signalling to the stem cells is promoted by AGO1 and subsequently maintained by a provascular ZLL-dependent signalling pathway."
Identification of microRNAs involved in pathogen-associated molecular pattern-triggered plant innate immunity.
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AGO1 contributes to PAMP-triggered immunity through miRNA pathways.
"the Arabidopsis (Arabidopsis thaliana) miRNA effector protein, Argonaute1 (AGO1), is required for a number of PTI responses including PAMP-induced callose deposition, gene expression, and seedling growth inhibition."
Suppression of Arabidopsis ARGONAUTE1-mediated slicing, transgene-induced RNA silencing, and DNA methylation by distinct domains of the Cucumber mosaic virus 2b protein.
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The viral 2b-AGO interaction can alter nuclear distribution of AGO proteins.
"the 2b-AGO interactions in vivo also required the nucleolar targeting of 2b and had the potential to redistribute both the 2b and AGO proteins in nucleus."
The microRNA pathway genes AGO1, HEN1 and HYL1 participate in leaf proximal-distal, venation and stomatal patterning in Arabidopsis.
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ago1 and other miRNA-pathway mutants reveal roles in leaf polarity and patterning.
"The morphological and histological characterization of these mutants and of dicer-like1-9 indicates that small RNAs participate in the proximal-distal and adaxial-abaxial patterning of leaves"
Ago hook and RNA helicase motifs underpin dual roles for SDE3 in antiviral defense and silencing of nonconserved intergenic regions.
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AGO1 associates with the GW-repeat-containing helicase SDE3 in silencing complexes.
"SDE3 is present with the PTGS effectors AGO1 and AGO2 in higher-order protein complexes owing to a specialized GW-repeat-containing C-terminal domain."
MicroRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis.
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AGO1 associates with the ER, where miRNA-mediated translational repression occurs.
"AGO1 is a peripheral ER membrane protein that is also possibly associated with the rough ER."
Functional and Genetic Analysis Identify a Role for Arabidopsis ARGONAUTE5 in Antiviral RNA Silencing.
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AGO1 antiviral capacity against suppressor-deficient PVX does not imply that it restricts wild-type PVX like AGO2/5.
"all Arabidopsis AGO proteins have the potential to target PVX lacking its viral suppressor of RNA silencing (VSR), P25, but that only AGO2 and AGO5 are able to target wild-type PVX."
In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings.
RISC-interacting clearing 3'- 5' exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana.
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AGO1 associates with RICE cofactors that clear uridylated cleavage fragments.
"We showed that RICE1 and its genetic paralog, RICE2, interacted with both AGO10 and AGO1"
Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling.
Degradation of unmethylated miRNA/miRNA*s by a DEDDy-type 3' to 5' exoribonuclease Atrimmer 2 in Arabidopsis.
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AGO1 interacts with ATRM2 in small-RNA surveillance.
"Finally, we show that ATRM2 colocalizes and physically interacts with Argonaute 1 (AGO1)."
Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1.
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AGO1-bound miRNAs are accessible to SDN1-mediated trimming.
"SDN1 interacts with the AGO1 PAZ domain in an RNA-independent manner in vitro, enabling it to act on AGO1-bound microRNAs."
Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method.
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RNA interactome capture directly detects AGO1 among leaf RNA-binding proteins.
"we identified the well-characterised RBPs AGO1 and AGO2, which are involved in RNAi"
Ribosome stalling caused by the Argonaute-microRNA-SGS3 complex regulates the production of secondary siRNAs in plants.
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An Argonaute-miRNA-SGS3 complex stalls ribosomes and couples translational regulation to secondary-siRNA production.
"ribosome stalling caused by the Argonaute-microRNA-SGS3 complex regulates production of secondary small interfering RNAs (siRNAs) in plants."
CONSTITUTIVE EXPRESSER OF PATHOGENESIS-RELATED GENES 5 is an RNA-binding protein controlling plant immunity via an RNA processing complex.
Phase separation of SGS3 drives siRNA body formation and promotes endogenous gene silencing.
ARGONAUTE1-binding Tudor domain proteins function in small interfering RNA production for RNA-directed DNA methylation.
AGO1 defines a novel locus of Arabidopsis controlling leaf development.
Falcon deep research for Arabidopsis AGO1
UniProt record for Arabidopsis AGO1
PANTHER PTHR22891 Argonaute/Piwi family entries
Heat stress promotes Arabidopsis AGO1 phase separation and association with stress granule components.
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Heat stress promotes AGO1 accumulation in cytoplasmic condensates associated with silencing-body and stress-granule components.
"AGO1 protein accumulation in cytosolic condensates where it colocalizes with components of siRNA bodies and of stress granules."
AGO1 re-review source audit and literature notes