EIF2S1 (eIF2alpha) review notes

Literature search (no deep-research provider available)

Sources checked: UniProt P05198 (curated FUNCTION, ACTIVITY REGULATION, SUBUNIT, PTM,
SUBCELLULAR LOCATION); all 32 GOA-cited PMIDs cached via just fetch-gene-pmids; additionally
fetched PMID:10613902 (Kedersha 1999, stress granules). Context only: the integrated stress response module and GO-CAM review proposed in
ai4curation/ai-gene-review#5904. The EIF2S1 GO-CAM mistyping is cited directly from
gocams/66b5638000001589/66b5638000001589-src.yaml and gocams/66b5638000000624/66b5638000000624-src.yaml.

Key findings

• eIF2 is a general initiation factor: PMID:16289705 whereas PMID:16289705.
• Ternary complex: PMID:23063529
• Phospho-eIF2 inhibits eIF2B: PMID:10613902
• Stress granules: PMID:10613902
• HRI/mitophagy: PMID:38340717; ER-marker check: PMID:38340717

GO-CAM term check (task question)

Yes: GOA carries GO:0160296 cap-dependent translation initiation factor activity (IDA, PMID:16289705,
assigned by UniProt, dated 2022-01-19 and 2024-08-19, deduplicated to one review row) and GO:0160297
IRES-mediated translation initiation factor activity (IDA, PMID:16289705, UniProt, 2024-08-19).
These mirror the GO-CAM typing. Both MODIFY to GO:0003743, with WRONG_TERM source_defects (resource UNIPROT).

Decisions

• GO:0010998 (regulation of translational initiation by eIF2 alpha phosphorylation) not proposed:
  it is_a GO:0006468 protein phosphorylation, i.e. the kinases' process; GOA carries it only on EIF2AK4 in this repo.
• Protein-binding rows (25) removed per protein-binding policy.
• translational initiation rows MODIFY to cytoplasmic translational initiation (GO:0002183).