Gene Ontology annotation through association of InterPro records with GO terms
Combined Automated Annotation using Multiple IEA Methods
UniProtKB entry for PSEPK ArgC1
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Curated catalytic chemistry or specific family classification supports the inferred target function.
"Catalyzes the NADPH-dependent reduction of N-acetyl-5-
CC glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde."
OpenScientist functional synthesis for PSEPK ArgC1
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The report identifies the exact accession as a type 1 ArgC protein and retrieves the NADPH-dependent AGPR reaction. Its claims that KT2440 lacks ArgA, that ArgC1 is the dominant isoenzyme, and that ArgC2 lacks intact catalytic motifs are contradicted or unsupported and are not used here.
"N-acetyl-L-glutamyl-5-phosphate + NADPH + H⁺ → N-acetyl-L-glutamate-5-semialdehyde + NADP⁺ + phosphate"
Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase from Mycobacterium tuberculosis in complex with NADP(+).