LCB1 notes (P25045, YMR296C)

• SPT subunit; LCB1 and LCB2 both required PMID:1556076; PMID:8058731.
• Heterodimer, mutual stability PMID:10713067.
• PLP Schiff-base lysine annotated only on Lcb2 (K366) [UniProt:P40970]; Lcb1 is the non-catalytic partner (as SPTLC1) -> core MF recorded as contributes_to; PLP-binding IEA on Lcb1 marked over-annotated.
• SPOTS complex PMID:20182505.
• IBA 'sphingosine biosynthetic process' -> MODIFY to sphingoid biosynthetic process (yeast makes DHS/PHS, no sphingosine).
• YeastPathways RCA cytosol -> REMOVE (integral ER membrane).
• Decisions: 8 PB REMOVE, cytosol RCA REMOVE, 2 MARK_AS_OVER_ANNOTATED (cytoplasm, PLP binding), 1 MODIFY, 1 KEEP_AS_NON_CORE (sphingolipid homeostasis NAS; Lcb1 is the regulated target of Orm1/2), 16 ACCEPT.