Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Rapid coevolution of the nematode sex-determining genes fem-3 and tra-2.
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RNAi in C. elegans, C. briggsae and C. remanei shows the male-promoting function of fem-3 and its epistatic relationship with the upstream repressor tra-2 are conserved across all three species.
"the male-promoting function of fem-3 and its epistatic relationship with its female-promoting upstream repressor, tra-2, are conserved"
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FEM-3 binds TRA-2 directly, but the interaction is strictly species-specific and the FEM-3/TRA-2 interface is rapidly coevolving.
"the FEM-3 protein interacts with TRA-2 in each species, but in a strictly species-specific manner"