GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000118

TreeGrafter-generated GO annotations

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:32808929

The dynamic nature of the human origin recognition complex revealed through five cryoEM structures.

Human ORC2-5 forms a compact stable core, and the ORC5-ORC3 interface is a hinge that may facilitate DNA binding.

"The absence of ORC1 revealed a compact, stable complex of ORC2-5."

file:EQUAS/ORC5/ORC5-bioinformatics/human_O43913-uniprot.txt

UniProtKB Swiss-Prot record O43913 (human ORC5), fetched 2026-10-14

file:EQUAS/ORC5/ORC5-bioinformatics/RESULTS.md

ORC5: donkey-human sequence comparison

file:EQUAS/ORC5/ORC5-bioinformatics/RESULTS-rereview.md

ORC5 donkey gene models vs human/mouse/horse ORC5 (re-review)

A0A9L0JAR4 is one of ten UniProt products of the single donkey ORC5 gene ENSEASG00005017348; it matches human ORC5 through residue 421 but carries an alternative C-terminal segment, whereas A0A9L0I6Y4 (435 aa) has the full canonical mammalian ORC5 C-terminus.

"Benchmark accession A0A9L0JAR4: length 440, identity 94.84% to human over 426 paired residues; C-terminus RGPPKTCLQTHKNRLTMSSH; human-type C-terminus present: False."

PMID:17716973

ATP-dependent assembly of the human origin recognition complex.

ATP binding by human ORC4 and ORC5 is required for ORC assembly in vitro.

"Mutations in the ATP-binding sites of Orc4 or Orc5"

PMID:31160578

The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing.

Chromatin-bound human ORC3 and ORC5 are multi-mono-ubiquitylated by OBI1 in S phase, promoting origin firing.

"Altogether, these results showed that chromatin-bound ORC3/5 become multi-mono-ubiquitylated concomitantly with origin firing."