akt-1 (Q17941) review notes

Deep research: falcon run failed (timeout/connection reset; perplexity fallback unavailable). Review based on cached publications, UniProt and PubMed.

Key findings

• Indispensable for DAF-2 signalling, antagonises DAF-16 PMID:9716402
• Kinase complex and DAF-16 phosphorylation PMID:15068796
• SKN-1 phosphorylation PMID:18358814
• PIP3 binding / membrane recruitment PMID:25383666
• Anti-apoptotic, cep-1-dependent PMID:17276923

Curation decisions

• Protein binding rows: substrates (DAF-16, MDF-1) REMOVE; kinase partners (SGK-1, AKT-2) -> protein kinase binding; PPTR-1 -> protein phosphatase 2A binding.
• p53-class DNA-damage apoptosis IMP -> negative regulation (GO:1902166).
• IBA positive regulation of blood vessel endothelial cell migration REMOVE (no vasculature in nematodes).