Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10660536

Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells.

Human Rab24 is predominantly GTP-bound, has low GTPase activity, is inefficiently prenylated, and is partly membrane-associated.

PMID:16034420

Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.

Rabenosyn-5/ZFYVE20 recognizes Rab GTPases through selective Rab-effector interactions, providing context for the RAB24 interaction but not a specific GO molecular function beyond Rab GTPase activity.

PMID:20562859

Network organization of the human autophagy system.

PMID:32296183

A reference map of the human binary protein interactome.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

PMID:34800366

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

PMID:35271311

OpenCell: Endogenous tagging for the cartography of human cellular organization.

Reactome:R-HSA-6798743

Exocytosis of secretory granule membrane proteins

file:human/RAB24/RAB24-uniprot.txt

UniProtKB record for human RAB24

UniProt summarizes RAB24 as an atypical Rab protein with low GTPase activity, predominant GTP-bound state, basal late-autophagic-vacuole clearance, and by-similarity oocyte meiotic apparatus context.

file:human/RAB24/RAB24-notes.md

RAB24 review notes

Manual PN-focused curation notes for RAB24; PN no-PMID rows were treated as context only.

PMID:26325487

RAB24 facilitates clearance of autophagic compartments during basal conditions.

RAB24 localizes to autophagic vacuoles/autophagic compartments and supports maturation/clearance of late basal autophagic compartments without affecting autophagosome formation.

file:human/RAB24/RAB24-deep-research-falcon.md

Falcon deep research report for RAB24

LLM-synthesized literature report agreeing that RAB24 is an atypical Rab with low intrinsic GTPase activity, predominantly GTP-bound, prenylation-dependent membrane targeting, and a late-stage basal-autophagy clearance role; it additionally surfaces the Rab7/RILP late-endosomal degradation interaction (Amaya 2016) and immuno-EM localization to both inner and outer autophagic-vacuole membranes.