GO_REF:0000104

Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

file:genes/STAAT/fosB/fosB-uniprot.txt

UniProt flat file for fosB (A8Z522)

UniProt names FosB as a metallothiol transferase that adds a thiol cofactor to fosfomycin.

"catalyzing the addition of a thiol cofactor to"

PMID:23256780

Mechanistic studies of FosB: a divalent-metal-dependent bacillithiol-S-transferase that mediates fosfomycin resistance in Staphylococcus aureus.

SaFosB preferentially uses bacillithiol and produces a bacillithiol-fosfomycin product.

"confirm that bacillithiol (BSH) is its preferred physiological thiol substrate"

PMID:17986343

Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus.

Genome-sequence source for the USA300/TCH1516 entry, not primary evidence for FosB mechanism.

"USA300-MRSA 2658 chromosomal open reading frames were predicted"

file:projects/ANTIMICROBIAL_RESISTANCE/aro2go.sssom.yaml

Curated ARO to GO mapping set for AMR gene families

The AMR mapping explicitly excludes FosB from glutathione transferase propagation.

"The parent node also contains FosB (bacillithiol/L-cysteine thiol transferase, NOT"