HAC1 (S. cerevisiae, P41546) review notes

Deep research: not run (falcon times out in this environment; perplexity-lite unavailable).
Review based on cached GOA-cited publications and the UniProt entry.

Key findings

• bZIP transcription factor of the yeast UPR; binds UPRE and activates transcription
  PMID:9077435
• Required for the UPR; protein made only in UPR-activated cells via Ire1-dependent mRNA splicing
  PMID:8898193
• Hac1i represses early meiotic genes via Rpd3-Sin3 HDAC
  PMID:15141165

Curation decisions

• meiotic cell cycle (IDA/IMP) -> MODIFY to GO:0051447 negative regulation of meiotic cell cycle.
• Repression of Pol II transcription kept as non-core.
• Core MF: GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific.