Falcon deep research report for TPM1
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Falcon corroborates TPM1 as an actin-filament tropomyosin whose core roles are sarcomeric thin-filament regulation in muscle isoforms and stress-fiber/focal-adhesion actin network specification in non-muscle isoforms.
"TPM1 encodes alpha-tropomyosin, a coiled-coil actin-binding thin-filament protein that regulates actin-myosin interaction in a Ca2+/troponin-dependent manner in cardiac muscle."
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Hypertrophic cardiomyopathy caused by a novel alpha-tropomyosin mutation (V95A) is associated with mild cardiac phenotype, abnormal calcium binding to troponin, abnormal myosin cycling, and poor prognosis.
Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy.
Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing.
Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta.
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
Towards a proteome-scale map of the human protein-protein interaction network.
Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study.
Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity.
Role of high-molecular weight tropomyosins in TGF-beta-mediated control of cell motility.
Nebulette interacts with filamin C.
Next-generation sequencing to generate interactome datasets.
MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremities.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
A reference map of the human binary protein interactome.
Human hTM alpha gene: expression in muscle and nonmuscle tissue.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere.
Release Of ADP From Myosin
Release Of ADP From Myosin