Gene Ontology annotation through association of InterPro records with GO terms

Electronic Gene Ontology annotations created by ARBA machine learning models

Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript.

Drosophila Pcf11 is required for Pol II termination at hsp70 and dismantles paused elongation complexes by bridging the CTD to nascent RNA.

"dPcf11 forms a bridge between the CTD and RNA."

PMID:39111825

A developmental mechanism to regulate alternative polyadenylation in an adult stem cell lineage.

The Pcf11-RC transcript is predicted to encode a ~10 kDa protein with only part of the CID, and no corresponding protein was detected in testis by anti-Pcf11 (aa 1-283) western blot.

"no protein product corresponding to PCF11-RC was observed despite a seemingly high level of the PCF11-RC transcript isoform detected by snRNA-seq of Drosophila testis tissue"
Long Pcf11 isoforms associate with Cbc in CFII.

"coimmunoprecipitated the >250 kDa band from the PCF11 isoforms, consistent with the Cbc and PCF11 proteins interacting in a complex"

PMID:22690379

Identification of Inverse Regulator-a (Inr-a) as Synonymous with Pre-mRNA Cleavage Complex II Protein (Pcf11) in Drosophila.

PMID:12727883

Independent functions of yeast Pcf11p in pre-mRNA 3' end processing and in transcription termination.

PMID:30139799

Reconstitution of mammalian cleavage factor II involved in 3' processing of mRNA precursors.

file:DROME/Pcf11/Pcf11-uniprot.txt

DROME/Pcf11/Pcf11-uniprot.txt

file:DROME/Pcf11/Pcf11-bioinformatics/RESULTS-rereview.md

Pcf11 isoform comparison (re-review, 2026-10-20)

C0P8M6 is identical to E1JH69 (isoform C), shares only residues 1-62 with the long Pcf11 products and retains about 38% of the CID.

"C0P8M6 retains residues 11-62 of the CID (about 38% of it) plus an unrelated C-terminal tail."

file:DROME/Pcf11/Pcf11-deep-research-flybase.md

FlyBase gene description for Pcf11 (DROME)