trpA (PA0035, P07344) review notes

No deep-research provider was available; notes compiled from the UniProt entry and the cached publication.

Tryptophan synthase alpha chain; HAMAP MF_00131, TIGR00262. UniProt function (HAMAP): "The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate."
trpBA gene order with 4-bp overlap PMID:3127651.
In vivo complementation: PMID:3127651. Abstract only in cache; PMC full text not available (no PMCID).

PseudoCAP IBA-seed assessment

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	other seeds	IBD stands without this seed?	verdict	rationale
PTN000034360	GO:0000162 L-tryptophan biosynthetic process	3	151 (80 taxa)	GO:0000162, IDA, PMID:3127651 (PseudoCAP)	E. coli TrpA P0A877; Arabidopsis TSA1 AT3G54640	Yes (E. coli TrpA is the reference enzyme)	SOUND	Heterologous in vivo complementation shows the alpha subunit works in Trp synthesis; evidence is complementation rather than a direct assay, but the term is right. Node term suits a TrpA clade.

No source defects. Actions: 7 ACCEPT.