Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade.

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.

Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage.

Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway.

Expression of the Bcl-2 protein BAD promotes prostate cancer growth.

Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.

A proteome-scale map of the human interactome network.

Widespread macromolecular interaction perturbations in human genetic disorders.

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.

Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant.

NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus.

Maximizing binary interactome mapping with a minimal number of assays.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

A reference map of the human binary protein interactome.

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.

RAIDD is a new 'death' adaptor molecule.

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.

PIDD1 associates with CRADD

The PIDDosome activates CASP2

The PIDDosome binds CASP2

Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex.

Genetic mapping and exome sequencing identify variants associated with five novel diseases.

Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.

DRONC, an ecdysone-inducible Drosophila caspase.

HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains.

HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.

The finished DNA sequence of human chromosome 12.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment.

Total recall: the role of PIDDosome components in neurodegeneration.

CRADD primary-source access and short excerpts