coq6 (Q9Y7Z9, SPBC146.12) review notes

Sources

No deep-research provider output is available (no provider API keys in this
environment). The review rests on the UniProt record (HAMAP MF_03193) and the cached
literature; PMID:24911838 and PMID:38425362 were read in full, PMID:38295803 from the
abstract.

Literature

• Deletion abolishes CoQ10; human COQ6 complements PMID:24911838
• Electron supply: by homology via ferredoxin reductase and ferredoxin PMID:24911838 In S. pombe this is still a proposal
  PMID:37156397
• C1 hydroxylation conflict: human COQ6 hydroxylates C1 in vitro PMID:38425362, whereas COQ4 performs both C1 reactions
  in vivo PMID:38295803

Audit decisions (2026-11)

• GO:0120538 (C1 hydroxylase, IEA from HAMAP) changed from ACCEPT to
  MARK_AS_OVER_ANNOTATED: real in vitro activity of the human ortholog, disputed in vivo.
  Siblings disagree (yeast COQ6 REMOVE, human COQ6 ACCEPT with IDA); flagged for the
  coordinator. Suggested question added.
• GO:0016712 changed from MARK_AS_OVER_ANNOTATED to MODIFY -> GO:0106364 (wrong donor
  class, monooxygenase essence sound), matching the S. cerevisiae COQ6 review.
• Core function GO:0106364 (C5 hydroxylation) agrees with the module.