Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
Functional analysis of Sox8 during neural crest development in Xenopus.
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Sox8 is the first SoxE expressed at the lateral neural plate edges at mid-gastrula; knockdown delays neural crest progenitor induction and blocks crest migration, disrupting multiple crest lineages.
"the control of Sox8 expression at the neural plate border is a key process in initiating neural crest formation in Xenopus"
SoxE factors function equivalently during neural crest and inner ear development and their activity is regulated by SUMOylation.
Pax3 and Zic1 drive induction and differentiation of multipotent, migratory, and functional neural crest in Xenopus embryos.
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Inducible Pax3/Zic1 activate sox8 among the earliest NC specifiers (with snail1 and myc), before foxd3/sox9 and snail2/sox10.
"a group of early genes ( snail1 , sox8 , and myc ) was activated during early neurulation (between stages 12 and 15)"
Identification of Pax3 and Zic1 targets in the developing neural crest.
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sox8 is among the genes induced by combined Pax3/Zic1 activity in a microarray screen (not shown to be direct).
"This group included 10 well-characterized NC-specific genes: ednra, foxd3, gbx2, olig4, snail2, sox8, sox9, tcf7, twist and zic5"
A transition from SoxB1 to SoxE transcription factors is essential for progression from pluripotent blastula cells to neural crest cells.
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Sox8 has low blastula expression that is lost by gastrulation and reappears in NC regions at mid-gastrula.
"A third SoxE factor, Sox8, is expressed at low levels in blastula stage embryos but is not detectable by the onset of gastrulation"
Sorting Sox: Diverse Roles for Sox Transcription Factors During Neural Crest and Craniofacial Development.
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In Xenopus sox8 is the first SoxE in the crest, unlike chick/mouse (Sox9 first) and zebrafish (sox8 not in crest); Sox8 morphants are rescued by any SoxE.
"In Xenopus, sox8 is expressed first followed by sox9 then sox10"
A time-resolved single-cell roadmap of the logic driving anterior neural crest diversification from neural border to migration stages.
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sox8 marks the early/immature neural crest programme in Xenopus single-cell data.
"gene programs that define early and immature neural crest cells (e.g. expression of snail2, foxd3, and sox8 genes)"
Sox8: a multifaceted transcription factor in development and disease.
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SoxE HMG domain binds and bends DNA; mammalian Sox8 is largely redundant with Sox9/Sox10; SoxE duplications were independent in agnathans and gnathostomes.
"SoxE genes independently duplicated from a common ancestor in the vertebrate groups of agnathans (primitive jawless fishes) and gnathostomes (jawed vertebrates)"
SoxE gene duplication and development of the lamprey branchial skeleton: Insights into development and evolution of the neural crest.
Novel Tfap2-mediated control of soxE expression facilitated the evolutionary emergence of the neural crest.
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Amphioxus soxE lacks proximal neural crest enhancers, implying cis-regulatory recruitment of SoxE into the crest in vertebrates.
"neural crest enhancers are not detected proximal to amphioxus soxE"
Falcon deep research report on Xenopus laevis sox8
UniProtKB entry Q6VVD7 (SOX8_XENLA)