Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis.
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.
Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis.
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.
Caspase-10 is an initiator caspase in death receptor signaling.
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases.
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease.
Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells.
Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.
Calcium binding of ARC mediates regulation of caspase 8 and cell death.
A human protein-protein interaction network: a resource for annotating the proteome.
The role of receptor internalization in CD95 signaling.
Engineered hybrid dimers: tracking the activation pathway of caspase-7.
Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.
Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells.
Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation.
Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling.
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.
A novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression.
FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies.
Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis.
Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8.
Identification of a critical tyrosine residue in caspase 8 that promotes cell migration.
Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein.
No death without life: vital functions of apoptotic effectors.
Yes and PI3K bind CD95 to signal invasion of glioblastoma.
A pathway sensor for genome-wide screens of intracellular proteolytic cleavage.
TNF-alpha induces two distinct caspase-8 activation pathways.
Identification of an antiapoptotic protein complex at death receptors.
ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development.
Huntingtin promotes cell survival by preventing Pak2 cleavage.
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling.
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.
Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function.
Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity.
Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema.
Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.
NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling.
TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8.
Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation.
The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms.
DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD.
PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo.
Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway.
Toward an understanding of the protein interaction network of the human liver.
RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis.
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome.
Pick your poison: the Ripoptosome, a cell death platform regulating apoptosis and necroptosis.
Vesicles released by activated T cells induce both Fas-mediated RIP-dependent apoptotic and Fas-independent nonapoptotic cell deaths.
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.
A type III effector antagonizes death receptor signalling during bacterial gut infection.
Involvement of caspase 8 and c-FLIPL in the proangiogenic effects of the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL).
Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity.
TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-mediated expression of Fas.
The seventh zinc finger motif of A20 is required for the suppression of TNF-α-induced apoptosis.
An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers.
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.
Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.
A protein interaction landscape of breast cancer.
Calmodulin Binding Activates Chromobacterium CopC Effector to ADP-Riboxanate Host Apoptotic Caspases.
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells.
Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).
Casper is a FADD- and caspase-related inducer of apoptosis.
p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum.
Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses.
ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.
Caspase-8 activates BID by cleavage
Caspase-8 processing in the DISC
TRAIL-mediated dimerization of procaspase-8
TNF-mediated dimerization of procaspase-8
Caspase-mediated cleavage of plectin-1
TLR4-induced ripoptosome assembly
Caspase-8 processing within TLR4 complex
Viral serpin blocks caspase-8 activity
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
FLIP(L) and procaspase-8 form heterodimer in TNF signaling
FLIP(S) and procaspase-8 form heterodimer
Caspase-8 and FLIP(L) processing at DISC
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
Caspase mediated cleavage of vimentin at IDVD (259)
Translocation of active caspase-8 to the mitochondrial membrane
Caspase mediated cleavage of BAP31
RIPK1 is cleaved by CASP8
Regulation of TNFR1 signaling
TRAF1 is cleaved by caspases
ASC binds Caspase-8 complex
Caspase-8 cleaves IL1B precursor
FLIP(L) and procaspase-8 form heterodimer
Viral inhibitor of caspase-8 activation (UL36) binds caspase-8
NOD1 induced apoptosis is mediated by RIP2 and CARD8
FAS-mediated dimerization of procaspase-8
TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8
TRADD:TRAF2:RIP1:FADD binds pro-caspase 8
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
TLR3-induced ripoptosome assembly
Caspase-8 processing within TLR3 complex
Dimerzation of procaspase-8, procaspase-10
Recruitment of caspase-8 and -10 to FADD complex
Recruitment of IKK complex
RIPK3 is cleaved by CASP8
RIPK1 variant is not cleaved by CASP8
Caspase-8 and FLIP(L) processing at TNFR signaling complex
RIPK1 is cleaved by CASP8:FLIP(L)
CASP8 cleaves N4BP1 at D424, D490
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.
Reviewed human CASP8 UniProt record Q14790
Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor.