lolA (PA2614, Q9I0M4) notes

Periplasmic lipoprotein carrier of the Lol pathway. No deep-research provider was available;
literature checked by hand (PMID:17350955 abstract only; PMID:26621210 full text, fetched with
ai-gene-review fetch-pmid; QuickGO for E. coli LolA P61316). Consistent with the PA2988 and
PA2986 (LolCDE permease) reviews of the same paper.

Literature

Tanaka, Narita & Tokuda 2007 (PMID:17350955, abstract): reconstituted P. aeruginosa LolCDE
released lipoproteins to the P. aeruginosa LolA homologue ["When incubated in the presence of
ATP and a LolA homologue, the reconstituted LolCDE homologue released lipoproteins, leading to
the formation of a LolA-lipoprotein complex."], and LolB then inserted them in the outer
membrane; E. coli LolCDE also transfers lipoproteins to P. aeruginosa LolA.
Fernández-Piñar et al. 2015 (PMID:26621210, full text): lolA essential; LolA-depleted cells
are SDS-sensitive and partly attenuated in Galleria and mouse infection ["In the whole, this
experiment demonstrates that LptH and, to a lesser extent, LolA are the only proteins here
investigated with a relevant role in cell envelope stability."]. Necessity evidence only.
E. coli LolA P61316: IDA GO:0044874 (CACAO, PMID:7628437), IDA GO:0030288. The E. coli lolA
review uses GO:0140598 lipoprotein carrier activity as the core MF.

Review decisions

GO:0044874 (IDA, IBA, IEA), GO:0042953 (IBA, IEA), GO:0030288 IBA: ACCEPT.
GO:0042597 periplasmic space IEA: TOO_GENERAL (entailed by accepted GO:0030288).
NEW GO:0140598 lipoprotein carrier activity, IDA PMID:17350955.

PseudoCAP IBA-seed assessment

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN002185387	GO:0044874 lipoprotein localization to outer membrane	2	9 (9 taxa)	GO:0044874, IDA, PMID:17350955 (PseudoCAP; also CACAO)	SOUND	Abstract states the purified P. aeruginosa LolA accepts lipoproteins from LolCDE and LolB inserts them in the outer membrane: direct biochemical evidence. Node term suits a LolA clade.	E. coli LolA P61316 (CACAO IDA GO:0044874, PMID:7628437)	Yes, on E. coli LolA

No PSEUDOCAP or GO_CENTRAL defect.