Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
DROME/NtR/NtR-family-evidence.md
DROME/NtR/NtR-flybase.txt
Improved reference genome of Aedes aegypti informs arbovirus vector control.
Falcon research on NtR/CG6698/Q9W288
-
No direct ligand-binding or electrophysiological experiment was located by the provider.
"No ligand-binding or electrophysiological experiment establishes association with a neuronal channel."
-
The report recognizes neuronal-channel ligand-binding domains but underweights their concordance with the independently verified family tree.
"**Neur_chan_LBD:** Pfam **PF02931**."
NtR Cys-loop hallmark residue comparison (re-review)
-
NtR lacks the loop-C vicinal cysteines of acetylcholine-binding alpha subunits.
"the nAChRalpha2 C243-C244 and CHRNA7 vicinal Cys pair, which defines acetylcholine-binding alpha subunits, aligns with NtR M412-M413"
-
NtR lacks the M2 GEK cation-selectivity ring conserved in nAChRs.
"all three references share the GEK motif at the intracellular end of M2"