Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Combined Automated Annotation using Multiple IEA Methods
Formation and operation of the histidine-degrading pathway in Pseudomonas aeruginosa.
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Histidase, urocanase and FIGLU-degrading activity (steps I, II and IV) are induced by urocanate and subject to catabolite repression in P. aeruginosa; step III (imidazolonepropionase) is not mentioned in the abstract.
"Histidine ammonia lyase (histidase), urocanase, and the capacity to degrade formiminoglutamate, which are respectively involved in steps I, II, and IV in the catabolism of histidine"
A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis.
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B. subtilis HutI is a TIM-barrel metallo-dependent hydrolase with an active-site zinc that hydrolyses 4-imidazolone-5-propionate to FIGLU.
"X-ray fluorescence scan analysis confirmed that the bound metal ion was a zinc ion."
Annotating enzymes of unknown function: N-formimino-L-glutamate deiminase is a member of the amidohydrolase superfamily.
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In P. aeruginosa, HutH, HutU and HutI convert histidine to FIGLU; PA5106 (HutF) and PA5091 (HutG) and PA3175 (HutE) degrade FIGLU.
"The first three steps for the degradation of histidine include the action of HutH, HutU, and HutI to convert L-histidine to N-formimino-L-glutamate."
Genetic analysis of the histidine utilization (hut) genes in Pseudomonas fluorescens SBW25.
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The HutH, HutU and HutI steps are shared by the four-step and five-step hut pathways.
"are common to both the four-step and the five-step pathways"
The origin and ecological significance of multiple branches for histidine utilization in Pseudomonas aeruginosa PAO1.
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P. aeruginosa PAO1 has two FIGLU-to-glutamate branches downstream of HutI.
"the histidine uptake and utilization (hut) pathway of Pseudomonas aeruginosa PAO1 contains two branches from the intermediate formiminoglutamate to the product glutamate"
X-ray structure of imidazolonepropionase from Agrobacterium tumefaciens at 1.87 A resolution.
Global regulation and virulence mediated by the histidine-responsive local transcription factor HutC in Pseudomonas aeruginosa.