Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase.
The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair.
Towards a proteome-scale map of the human protein-protein interaction network.
Large-scale mapping of human protein-protein interactions by mass spectrometry.
LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
A proteome-scale map of the human interactome network.
The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing.
Regulation of spindle integrity and mitotic fidelity by BCCIP.
The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma.
A reference map of the human binary protein interactome.
BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Cyberian deep research on BCCIP function
Falcon deep research on BCCIP isoform-resolved function
OpenScientist report on BCCIPalpha inhibition of FAM46/TENT5 polymerases
-
The OpenScientist report recommends isoform-specific enzyme inhibitor activity for BCCIPalpha, supported by structural and biochemical evidence of active-site blockade.
"The strongest recommendation is to annotate BCCIPalpha with **GO:0004857 "enzyme inhibitor activity"** using evidence code IDA, referencing [PMID: 37018411](https://pubmed.ncbi.nlm.nih.gov/37018411/), with an isoform-specific qualifier."
-
Cellular RNA targets and process-level consequences of BCCIPalpha-mediated TENT5 inhibition remain untested.
"No transcriptomic, TAIL-seq, or poly(A) tail-length profiling data exist linking BCCIPalpha expression to changes in TENT5 target RNA metabolism."