Gene Ontology annotation through association of InterPro records with GO terms
ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism.
Falcon deep research report for ABCA7
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Falcon deep research corroborates ABCA7 as an ATP-driven phospholipid floppase/transporter (cryo-EM open/closed states) and surfaces a mitochondrial phospholipid (phosphatidylglycerol/cardiolipin) phenotype on ABCA7 loss.
"ABCA7 knockout reduced phosphatidylglycerol and cardiolipin; phosphatidylglycerol or NMN partially rescued phenotypes."
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux.
Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein.
Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release.
Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants.
ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing.
Lysophosphatidylcholine export by human ABCA7.
Quantitative fragmentomics allow affinity mapping of interactomes.
ABC transporters in lipid homeostasis
ABCA7:Apo1A-mediated phospholipid efflux