Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation.
Caspase activation is required for terminal erythroid differentiation.
Specific involvement of caspases in the differentiation of monocytes into macrophages.
ASAP, a novel protein complex involved in RNA processing and apoptosis.
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.
Death by splicing: tumor suppressor RBM5 freezes splice-site pairing.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold.
Dynamic protein-protein interaction wiring of the human spliceosome.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
The protein interaction landscape of the human CMGC kinase group.
Architecture of the human interactome defines protein communities and disease networks.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Multimodal cell maps as a foundation for structural and functional genomics.
Caspase-mediated cleavage of Acinus
Formation of the Spliceosomal B* complex
Formation of the Spliceosomal C* complex
Formation of the Spliceosomal B complex
Formation of the Spliceosomal Bact complex
Formation of the Spliceosomal P complex and exon ligation
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)
Formation of the Spliceosomal C complex containing intron lariat
UniProtKB record for human ACIN1
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex.
The RNA-binding profile of Acinus, a peripheral component of the exon junction complex, reveals its role in splicing regulation.
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iCLIP shows human Acinus binds pre-mRNAs (a subset of suboptimal introns) and spliced mRNAs as a peripheral EJC factor, and Acinus depletion alters inclusion of specific alternative cassette exons and faithful splicing of subsets of introns, indicating a direct role in exon and intron definition.
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Acinus regulates splicing of the DFFA/ICAD transcript, linking its splicing-regulatory activity to the apoptotic DNA fragmentation pathway.
Multifaceted Regulation of Gene Expression by the Apoptosis- and Splicing-Associated Protein Complex and Its Components.
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Reviews the RNPS1-Acinus-SAP18 ASAP complex (and an alternative Pinin-containing PSAP complex), its nuclear-speckle localization, EJC association, and roles spanning transcription, splicing, translation and nonsense-mediated decay.
Apoptosis Inhibitor 5: A Multifaceted Regulator of Cell Fate.