shop notes

• 2026-10-09: Initial review of shop (shopper; Q9VWP4; CG7280), sulfite oxidase.
• Otto et al. 2018 PMID:30158546 (full text): "The sulfite oxidase activity is drastically reduced upon
  lack of shopper ..."; "In S2 cells, ShopperHA is found in a punctate pattern co-localizing with the
  mitochondrial marker mitoGFP"; "shopper encodes a homolog of the human sulfite oxidase named SUOX,
  which localizes to the intermembrane space of mitochondria."; required in ensheathing glia.
  The text reports sulfite (not sulfate) measurements, so intracellular sulfate ion homeostasis IMP
  was marked over-annotated (supplements not checked).
• Martelli et al. 2024 PMID:38416643: ISOD model; "Adding sulfite (the substrate of sulfite oxidase)
  or thiosulfate to the Cys-free diet significantly reduced the health of shop larvae (and not
  controls)"; cysteine-free diet rescues.
• Mitochondrion rows (IBA/IEA/IDA) -> intermembrane space (TAS/IEA present); sulfur compound metabolic
  process -> sulfide oxidation; molybdenum ion binding -> molybdopterin cofactor binding.
• Falcon deep research (shop-deep-research-falcon.md, arrived after initial commit): sulfite oxidase
  activity assayed with cytochrome c as acceptor; ensheathing-glia rescue; in the 2024 metabolomics,
  sulfate was not significantly lower in mutants (other sulfate sources exist), which further supports
  marking intracellular sulfate ion homeostasis as over-annotated. No annotation changes.