Gene Ontology annotation through association of InterPro records with GO terms

Combined Automated Annotation using Multiple IEA Methods

Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction.

Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling.

Annotation inferences using phylogenetic trees

Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults.

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Novel binding motif of ACTH analogues at the melanocortin receptors.

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family.

The cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutants.

Functional characterization of a new human melanocortin-4 receptor homozygous mutation (N72K) that is associated with early-onset obesity.

Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption.

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Functional characterization of mutations in melanocortin-4 receptor associated with human obesity.

Liganded Gs-activating GPCR acts as a GEF for Gs

Melanocortin receptors bind melanocortins

The Ligand:GPCR:Gs complex dissociates

Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.

Electronic Gene Ontology annotations created by ARBA machine learning models

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

A frameshift mutation in MC4R associated with dominantly inherited human obesity.

Molecular cloning, expression, and gene localization of a fourth melanocortin receptor.

Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas.

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms.

Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness.

Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency.

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

UniProtKB entry P32245 (MC4R_HUMAN), Melanocortin receptor 4

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.

Targeted disruption of the melanocortin-4 receptor results in obesity in mice.

Falcon deep research report for human MC4R