Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
A molecular chaperone for mitochondrial complex I assembly is mutated in a progressive encephalopathy.
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NDUFAF2 (B17.2L) is a paralog of the B17.2/NDUFA12 structural subunit and is a bona fide molecular chaperone essential for complex I assembly; a null mutation causes complex I deficiency rescued by re-expression.
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NDUFAF2 does not associate with the mature holoenzyme but binds an ~830 kDa late assembly intermediate and co-immunoprecipitates a subset of complex I structural subunits from human heart mitochondria.
Effects of the novel mitochondrial protein mimitin in insulin-secreting cells.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
A multi-scale map of cell structure fusing protein images and interactions.
Primary cilia formation requires the Leigh syndrome-associated mitochondrial protein NDUFAF2.
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I
NDUF subunits bind to form the FP subcomplex