Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase.
Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase.
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody.
Active cyclin B1-Cdk1 first appears on centrosomes in prophase.
Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue.
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.
Interaction of chromatin-associated Plk1 and Mcm7.
The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1.
Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation.
Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.
Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer.
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability.
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.
The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity.
RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.
TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity.
Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1.
Structure of the catalytic domain of human polo-like kinase 1.
The tumor suppressor CYLD regulates entry into mitosis.
Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1.
Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation.
Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis.
Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing.
Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.
sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1.
Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression.
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1.
Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.
HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.
Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo.
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression.
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.
Plk1-mediated phosphorylation of Topors regulates p53 stability.
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover.
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A.
Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery.
Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase.
Phosphorylation by polo-like kinase 1 induces the tumor-suppressing activity of FADD.
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase.
Sororin mediates sister chromatid cohesion by antagonizing Wapl.
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.
Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction.
Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis.
Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression.
Proteomic identification of Hsp70 as a new Plk1 substrate in arsenic trioxide-induced mitotically arrested cells.
Toward an understanding of the protein interaction network of the human liver.
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway.
Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis.
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1.
Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes.
A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis.
Centrobin controls mother-daughter centriole asymmetry in Drosophila neuroblasts.
Ubiquitylation-dependent localization of PLK1 in mitosis.
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.
Bod1 regulates protein phosphatase 2A at mitotic kinetochores.
Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways.
Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis.
PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.
Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response.
Architecture of the human interactome defines protein communities and disease networks.
Mutations in the microtubule-associated protein MAP11 (C7orf43) cause microcephaly in humans and zebrafish.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
A central chaperone-like role for 14-3-3 proteins in human cells.
RHINO directs MMEJ to repair DNA breaks in mitosis.
Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis.
Multimodal cell maps as a foundation for structural and functional genomics.
ANKLE1 processes chromatin bridges by cleaving mechanically stressed DNA.
Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.
Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase.
MAD2 converted to an inhibitory state via interaction with Mad1
MAD2 associates with the Mad1 kinetochore complex
Release of activated MAD2 from kinetochores
Regulation of KIF23 (MKLP1) by phosphorylation
Inactivation of Wee1 kinase
Regulation of KIF20A (MKL2) by phosphorylation
Inactivation of Myt1 kinase
Golgi Cisternae Pericentriolar Stack Reorganization
Down Regulation of Emi1 through Phosphorylation of Emi1
Phosphorylation of cohesin by PLK1 at centromeres
PP2A-B56 dephosphorylates centromeric cohesin
Association of cell cycle proteins with the APC/C:Cdh1 complex
Degradation of multiubiquitinated cell cycle proteins
Free APC/C phosphorylated by Plk1
Phosphorylation of the Emi1 DSGxxS degron by Plk1
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
PLK1 phosphorylates GORASP1
PLK1 hyperphosphorylates Condensin II complex
PLK1 binds phosphorylated condensin II complex
Condensation of Prophase Chromosomes
Phosphorylation of cohesin by PLK1 at chromosomal arms
ESPL1 (Separase) cleaves centromeric cohesin
Separation of sister chromatids
CDK1 phosphorylates CDCA5 (Sororin) at centromeres
Resolution of Sister Chromatid Cohesion
AJUBA facilitates AURKA autophosphorylation
AJUBA binds centrosome-associated AURKA
Nuclear Envelope Breakdown
AURKA phosphorylates PLK1
BORA binds PLK1 and AURKA
Cytosolic PLK1 translocates to the nucleus
Myosin phosphatase dephosphorylates PLK1
Kinetochore capture of astral microtubules
Plk1-mediated phosphorylation of Nlp
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
Loss of C-Nap-1 from centrosomes
Dissociation of Phospho-Nlp from the centrosome
Recruitment of Plk1 to centrosomes
Association of NuMA with microtubules
Recruitment of CDK11p58 to the centrosomes
Translocation of NuMA to the centrosomes
PLK1 phosphorylates FOXM1
FOXM1 stimulates PLK1 transcription
RAB3IP stimulates nucleotide exchange on RAB8A
C2CD3 binds the mother centriole
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
CP110 and CEP97 dissociate from the centriole
The distal appendage proteins recruit TTBK2
Recruitment of transition zone proteins
MARK4 binds ODF2 in the centriole
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
CDC42:GTP recruits DIAPH2-2 to kinetochores
AURKB phosphorylates DIAPH2-2 at kinetochores
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
Mitotic Metaphase/Anaphase Transition
Mitotic Telophase/Cytokinesis
PLK1 phosphorylates GTSE1
TPX2 binds AURKA at centrosomes
TPX2 promotes AURKA autophosphorylation
EML4 and NUDC in mitotic spindle formation
EML4 recruits NUDC to mitotic spindle
PLK1 phosphorylates FIRRM at S43
PLK1 phosphorylates FIRMM at S744
PPP1CC dephosphorylates PLK1
MITF-M-dependent PLK1 expression
PLK1 binds phosphorylated Gorasp1
Deep research report on PLK1