FERMT1 database review notes

The core retained database claims are integrin binding, focal-adhesion localization, cell-matrix adhesion and integrin signaling. Skin-specific Wnt/TGF-beta regulation, stem-cell proliferation, hair-cycle timing, basement-membrane organization and conditional ruffles are retained with their tissue and assay limits.

Two narrower claims remain unresolved: direct actin-filament binding from tagged donor colocalization, and nuclear import from steady-state nuclear protein distribution. Neither uncertainty negates the observed positive localization/signaling findings. The TGF-beta production source instead supports positive regulation of receptor signaling through latent-ligand availability; the existing GO:0030511 term is proposed as the replacement, without adding an annotation.

The broad migration term has a verified strict descendant in the direct lane's retained wound-spreading row. Integration must preserve that positive row before using TOO_GENERAL. No other hierarchy deletion is inferred merely from a label that sounds broader.

The partial candidate preserves all 31 original source objects, four natural products, nine original reference identities and all 12 unowned review objects. Description, status and core functions are left for synthesis. Four complete manual reference objects provide the actual primary source scopes; the three direct-owned original reference objects remain untouched. No new quotes, generic provider report or new GO assertion is created. The intake's genuine failed research-provider outcomes remain recorded in the intake; private raw traces were not read.

See the source guide, complete source-keyed decisions, donor-chain evidence, PAINT scope and product map for reproducible joins and explicit limitations.