UFO (UNUSUAL FLORAL ORGANS, FBX1, At1g30950; UniProt Q39090) curation notes
2026-10-05 — initial review (floral_meristem_identity module)
- Identity check: UFO_ARATH, Q39090, At1g30950. Correct.
- Falcon deep research attempted; provider failed (exit code 1). Notes from cached publications.
Genetics
- ufo affects floral meristem identity, whorl pattern, determinacy, and AP3/PI activation
PMID:7780306
- 35S::UFO activates AP3 only with LFY PMID:9016705
Mechanism
- F-box protein binding ASK (SKP1-like) proteins PMID:10607296; SCF(UFO) with CSN PMID:12724534; genetic interaction with CUL1 PMID:15047903.
- UFO-LFY physical interaction; recruitment to AP3 promoter; proteasome needed PMID:18287201.
- Ubiquitination link mostly dispensable; LFY-UFO-DNA complex at new cis-elements; cryo-EM PMID:36732360
Identifier issue
- One IPI protein binding row (PMID:10607296) has WITH/FROM UniProtKB:P43291, which is SnRK2.4/SRK2A (synonym "ASK1", a kinase). The paper concerns SKP1-like ASK proteins (ASK1 = SKP1A = Q39255). Likely an IntAct synonym mis-mapping of the partner; the UFO activity itself is fine (MODIFY to adaptor activity like other ASK rows).
Decisions
- ubiquitin-protein transferase activity (IBA, IMP) -> MODIFY to GO:1990756 ubiquitin-like ligase-substrate adaptor activity (F-box subunit is not catalytic).
- ASK protein binding rows -> MODIFY to GO:1990756; LFY binding -> MODIFY to GO:0140297.
- ubiquitin ligase complex -> MODIFY to GO:0019005 SCF ubiquitin ligase complex.
- NEW: GO:0003713 transcription coactivator activity (IDA, PMID:36732360) as the core MF.
- Proteolysis BP terms -> KEEP_AS_NON_CORE (no substrate known).