Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25.
Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta.
Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1.
Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase.
Identification of SAP97 as an intracellular binding partner of TACE.
TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.
Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23.
Tumor necrosis factor-alpha-converting enzyme controls surface expression of c-Kit and survival of embryonic stem cell-derived mast cells.
Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells.
ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands.
Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V.
Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling.
The shedding activity of ADAM17 is sequestered in lipid rafts.
EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing.
HDLs activate ADAM17-dependent shedding.
Tumor necrosis factor-alpha converting enzyme in the human placenta throughout gestation.
Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases.
The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells.
Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism.
UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes.
Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab.
Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex.
Tumor-associated MICA is shed by ADAM proteases.
Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice.
Defining the membrane proteome of NK cells.
ADAM17 (TACE) regulates TGFβ signaling through the cleavage of vasorin.
Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE.
A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by α5β1 integrin in kidney mesangial cells.
The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality.
TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
ADAM17-mediated shedding of FcγRIIIA on human NK cells: identification of the cleavage site and relationship with activation.
MiR-152 reduces human umbilical vein endothelial cell proliferation and migration by targeting ADAM17.
Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity.
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-α activation.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
MiR-338-3p inhibits the proliferation and migration of gastric cancer cells by targeting ADAM17.
iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.
FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.
CD9 Controls Integrin α5β1-Mediated Cell Adhesion by Modulating Its Association With the Metalloproteinase ADAM17.
GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17.
Tetraspanin 8 Subfamily Members Regulate Substrate-Specificity of a Disintegrin and Metalloprotease 17.
Quantitative fragmentomics allow affinity mapping of interactomes.
Tace/ADAM17 is a bi-directional regulator of axon guidance that coordinates distinct Frazzled and Dcc receptor signaling outputs.
ADAM17 variant causes hair loss via ubiquitin ligase TRIM47-mediated degradation.
A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells.
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.
TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha.
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor.
Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity.
alpha-secretase cleaves the p75NTR extracellular domain
TNF-α is cleaved by ADAM17 (TACE)
iRHOM2 transports ADAM17 from ER to the Golgi-network
iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane
PLK2, MAPK14 phosphorylate ADAM17
p-S,T-ADAM17(215-827):Zn2+ cleaves CD163
ADAM17 cleaves Notch1 at S2
Shh is released from the plasma membrane by ADAM17-mediated cleavage
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.
Manual ADAM17 curation notes