Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Automatic assignment of GO terms using logical inference, based on inter-ontology links.
Combined Automated Annotation using Multiple IEA Methods.
Stanniocalcin-1 is a naturally occurring L-channel inhibitor in cardiomyocytes: relevance to human heart failure.
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STC1 is upregulated in failing hearts and reduced after mechanical unloading
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STC1 inhibits L-type calcium channels in cardiomyocytes
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STC1 slows cardiomyocyte beating rate and reduces intracellular calcium transients
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STC1 shows diffuse cytoplasmic expression with nuclear predominance in cardiomyocytes
Stanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte growth factor.
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STC1 selectively inhibits HGF-induced endothelial migration and morphogenesis
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STC1 does not affect VEGF or bFGF-induced responses
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STC1 blocks HGF-induced focal adhesion kinase activation
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STC1 may serve as a stop signal for blood vessel maturation
Stanniocalcin 1 acts as a paracrine regulator of growth plate chondrogenesis.
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STC1 inhibits longitudinal bone growth at the growth plate
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STC1 increases phosphate uptake in chondrocytes
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Effects on growth are mediated through phosphate transport
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STC1 suppresses chondrocyte proliferation and differentiation
Stanniocalcin-1 regulates endothelial gene expression and modulates transendothelial migration of leukocytes.
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STC1 inhibits transmigration of macrophages and T lymphocytes
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STC1 does not affect neutrophil or B lymphocyte migration
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STC1 is detected on apical surface of endothelial cells in vivo
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STC1 may attenuate intracellular calcium signaling
Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A.
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STC1 is a potent inhibitor of PAPP-A (Ki = 68 pM)
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STC1 binds PAPP-A with high affinity (KD = 75 pM)
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STC1 forms homodimers via disulfide bonds
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STC1 antagonizes PAPP-A-mediated IGF receptor phosphorylation
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STC1 and STC2 are proteinase inhibitors specific for pappalysins
A reference map of the human binary protein interactome.
Human stanniocalcin: a possible hormonal regulator of mineral metabolism.
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First characterization of human STC1
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STC1 inhibits calcium transport in fish gills
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STC1 stimulates renal phosphate reabsorption in rats
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STC1 localizes to nephron tubules in kidney
Deep research report on STC1
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STC1 is a secreted dimeric glycoprotein functioning via autocrine/paracrine mechanisms
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STC1 is upregulated by hypoxia and stress pathways
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STC1 directly binds Notch1 in cancer contexts
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STC1 acts as a phagocytosis checkpoint through macrophage-centered effects
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High STC1 expression associated with poor cancer prognosis